![]() ( 1996), Thiaucourt and Bolske ( 1996), Kusiluka ( 2002), Nicholas and Churchward ( 2012), Samiullah ( 2013), AU-IBAR ( 2013), Prats-van der Ham et al. ![]() The chronological reviews on CCPP by Rurangirwa et al. Periodically, the disease dynamics are reviewed by researchers and agencies of national and international mandate and repute for keeping vigil on this transboundary emerging threat that endangers naive goat populations in various disease-free countries from the surrounding infected herds of neighboring and mutually cooperative countries. Considering the importance of this disease, worldwide measures are being taken for understanding this disease for better diagnosis, prevention, and control. Re-visiting conventional prophylactic measures focussing on developing novel strain-based or recombinant vaccines using specific antigens (capsular or cellular) should be the most important strategy for controlling the disease worldwide.Ĭontagious caprine pleuropneumonia (CCPP) is a highly contagious and rapidly spreading mycoplasmal disease that affects a vast majority of goat populations. Moreover, the studies on antibiotic sensitivity and exploration of novel antibiotics (fluoroquinolones, macrolides) can help in better therapeutic management besides preventing menace of antibiotic resistance. The latex agglutination test (LAT) is rapid, simple, and better test for field and real-time diagnosis applicable to whole blood or serum and is more sensitive than the CFT and easier than the cELISA. Diagnosis has overcome cumbersome and lengthy conventional tests involving culture, isolation, and identification by advanced serological (LAT, cELISA) or gene-based amplification of DNA (PCR, RFLP, and hybridization) and sequencing. Mycoplasmal antigen interactions with host immune system and its role in CCPP pathogenesis are not clearly understood. In later stages, severe lobar fibrinous pleuropneumonia, profuse fluid accumulation in pleural cavity, severe congestion of lungs and adhesion formation is observed. ![]() The characteristic clinical signs of CCPP are severe respiratory distress associated with sero-mucoid nasal discharge, coughing, dyspnea, pyrexia, pleurodynia, and general malaise. CCPP affects goats in more than 40 countries of the world thereby posing a serious threat to goat farming around the globe. The disease is characterized by severe serofibrinous pleuropneumonia, very high morbidity (∼100%), and mortality (80–100%). Contagious caprine pleuropneumonia (CCPP) is a serious disease of goats, occasionally sheep and wild ruminants, caused by Mycoplasma capricolum subspecies capripneumoniae (Mccp).
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